Via the microarray technique we can examine all 24 chromosomes. That's a great improvement comparing to what we could do before. More specifically, before the dna microarray technology we could only examine a limited number of chromosomes.
A huge advantage of the microarray technology is that we can have the results of the microarray data analysis in just one or two days, and so we can transfer fresh embryos instead of a FET (frozen embryo transfer).
Aneuploidies are chromosomal copy number changes. Chromosome aneuploidy is a major cause of IVF failure and pregnancy loss. Most aneuploidies arise during the final stage of egg development.
Aneploidies increase significantly with advanced maternal age. However, a recent study has shown that even in younger women a high percentage of blastocyst stage embryos are aneuploid.
Via the microarray method we can check aneuploidies in any of the cells which are available within an IVF cycle. Among these are first and second polar bodies, blastomere biopsies, and biopsies of the trophectoderm.
Microarray testing has shown to increase live birth rates per cycle started since an aneuploid embryo may be detected in every IVF cycle.
Dr Paraschos participated in the world's first PGD.