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Oocytes after ovulation are at metaphase II, stage in which meiotic spindle is formed. The meiotic spindle plays an important role in the oocyte during chromosome alignment and separation at meiosis. It has been reported that spindle abnormalities in oocytes during meiosis contribute to the aneuploidy in embryos after fertilization, poor embryo development, spontaneous abortion and inherited diseases. Spindle is a very fragile mechanism and it must be avoided during sperm injection. Studies have shown that the damage of metaphase spindle reduces fertilization and embryo development.

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Our desire and your passion for maternity had as a result the birth of two wonderful babies. You helped us not only physically but psychologically also since we never felt uncomfortable or unpleasant at the friendly environment of your center. At the moment besides the satisfaction and the tiredness of motherhood we also feel love and appreciation towards you and your center. A big thank you from my heart.
Pinelopi
Thanos Paraschos at EmBIO Medical Center with Professor Kypros Nikolaides,,
Professor of Fetal Medicine, King's College Hospital and founder of the Fetal Medicine Foundation
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